Propylene glycol is a synthetic organic compound with the chemical formula C3H2O2.   

It is a viscous colorless liquid which is nearly odorless but possesses a faintly sweet taste. Chemically it is classed as a diol and is miscible with a broad range of solvents, including water,and chloroform.

It is produced on a large scale and is primarily used in the production of polymers, but also sees use in food processing, and as a process fluid in low temperature heat exchange applications. In the European Union, it has the E-number E1520 for food applications.

The compound is sometimes called α-propylene glycol to distinguish it from the isomer propane-1, 3-diol (β-propylene glycol).

Propylene glycol is often used in electronic cigarettes to improve flavour and create a better throat hit. A bottle of flavored 'e-liquid' for 'vaping' shows propylene glycol as the main ingredient. Propylene glycol is commonly used to deice aircraft.

Propylene glycol is also used in various edible items such as coffee-based drinks, liquid sweeteners, ice cream, whipped dairy products and soda.

Vaporizers used for delivery of pharmaceuticals or personal-care products often include propylene glycol among the ingredients. Propylene glycol is used as a solvent in many pharmaceuticals including oral, injectable and topical formulations, such as for  and  which are insoluble in water. Certain formulations of artificial tears, such as Systane, use propylene glycol as an ingredient.

Like ethylene glycol, propylene glycol is able to lower the freezing point of water, and so it is used as aircraft deicing fluid. Water-propylene glycol mixtures dyed pink to indicate the mixture is relatively nontoxic are sold under the name of RV or marine antifreeze.

Propylene glycol is frequently used as a substitute for ethylene glycol in low toxicity, environmentally friendly automotive antifreeze. It is also used to winterize the plumbing systems in vacant structures.

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